Polyhexamethylene biguanide, hydrochloride;
PHMB hydrochloride;
CAS Number: 32289-58-0; 27083-27-8;

O cloridrato de PHMB, um agente antimicrobiano catiônico de amplo espectro, atinge o objetivo bactericida inibindo a atividade da membrana celular.

Como um agente antimicrobiano ativo na membrana celular, o PHMB inibe a atividade bacteriana melhor do que a dos fungos, e seu mecanismo antimicrobiano é mais ou menos o seguinte:
O PHMB é um composto catiônico polimerizado, que é facilmente adsorvido por vários tipos de bactérias que geralmente têm carga negativa, inibindo assim a função de divisão das bactérias e fazendo com que elas percam sua capacidade reprodutiva.

	PHMB 20% Solution	PHMB Solid
Appearance	Colorless clear to slightly pale yellow liquid	White to slight yellow hygroscopic powder
Odor	Characteristic	Characteristic
Turbidity [NTU]	Max. 10	—
Solid component [％]	19.0 to 21.0	Min. 95.0
Density at 20℃ [g/ml]	1.039 to 1.050	—
pH-Value at 25℃	4 to 6	4 to 7
Absorbance value (1%, 237nm)	Min. 400	Min. 400
Absorbance ratio (237nm / 222nm)	1.2 to 1.6	1.2 to 1.6

Abbreviation	Product Name	CAS No.	Appearance	Uses
Benzalkonium chloride	Quaternary ammonium compounds,benzyl-C12-14-alkyldimethyl, chlorides	85409-22-9	White Powder; Liquid	Powder is used in cosmetics, etc.
Benzyl Dodecyl Dimethyl Ammonium Bromide	Benzenemethanaminium, N-dodecyl-N,N-dimethyl-, bromide	7281-04-1	20% to 95%, Liquid to Paste
DDAC	Didecyldimethylammonium Chloride	7173-51-5	40%, 80% Liquid	Medical hygiene, wet wipes, cosmetics, etc.
CPC	Cetylpyridnium Chloride	123-03-5	White powder	Oral care, wet wipes, cosmetics, etc.
Benzethonium chloride	Benzethonium chloride	121-54-0	White powder	Wipes, lotion, etc.
C12 Benzyl Ammonium Bromide	Benzyl Dodecyl Dimethyl Ammonium Bromide	7281-04-1	White powder
Parabens	Methyl/ Ethyl/ Propyl/ Butyl paraben	—	White crystalline powder	Cosmetics, etc.
DBNPA	Acetamide,2,2-dibromo-2-cyano-	10222-01-2	White crystalline powder; Liquid	Algaecide in cooling water circulation system, etc.
Bronopol	2-Bromo-2-nitro-1,3-propanediol	52-51-7	White crystalline powder	Water treatment bactericide and algaecide, cosmetics, etc.
CMIT/MIT	3(2H)-Isothiazolone,5-chloro-2-methyl-,mixt. with 2-methyl-3(2H)-isothiazolone	55965-84-9	Liquid	Water treatment anti-slime and algaecide, etc.
PHMB	Poly(hexamethylenebiguanide) hydrochloride	32289-58-0; 27083-27-8;	Liquid
PHMG	Polyhexamethyleneguanidine hydrochloride; PHMG chloride	57028-96-3	Liquid	Water treatment, swimming pool, etc.
CHD-G	Chlorhexidine digluconate	18472-51-0	Liquid
CHD-A	Chlorhexidine di(acetate)	56-95-1	Liquid
	Zinc Castor Oleate	13040-19-2	Liquid	Odor scavenger

The following is the original English text.
A seguir, o texto original em inglês.

Polyhexamethylene biguanide, hydrochloride;
PHMB hydrochloride

CAS Number: 32289-58-0; 27083-27-8;
Formula:
1. CAS 32289-58-0: (C8H17N5·ClH)n; Poly(iminoimidocarbonyliminoimidocarbonyliminohexamethylene), hydrochloride;

2. CAS 27083-27-8: (C10H18N8·C6H16N2)x·xClH; Guanidine, N,N”’-1,6-hexanediylbis[N’-cyano-, polymer with1,6-hexanediamine, hydrochloride;

3. CAS: 91403-50-8; EC: 618-745-0;
IUPAC names: Poly(hexamethylenbiguanid)-hydrochlorid

PHMB hydrochloride, a cationic broad-spectrum antimicrobial agent, achieves bactericidal purpose by inhibiting cell membrane activity.

As a cell membrane active antimicrobial agent, PHMB inhibits bacterial activity better than that of fungi, and its antimicrobial mechanism is roughly as follows:
PHMB is a polymerized cationic compound, which is easily adsorbed by various types of bacteria that are usually negatively charged, thus inhibiting the division function of the bacteria and making the bacteria lose the ability to reproduce.

Features:
1. HPMB has the ability to inhibit Gram-positive bacteria, Gram-negative bacteria, fungi (many kinds of ringworm and mold) and yeast.
2. PHMB has rapid inhibitory effect on E. coli, Staphylococcus aureus and Candida albicans.
3. PHMB: LD50＞5000mg/kg, HPMB is skin friendly, human and environment friendly.

Technical Data:

	20% Solution	Solid
Appearance	Colorless clear to slightly pale yellow liquid	White to slight yellow hygroscopic powder
Odor	Characteristic	Characteristic
Turbidity [NTU]	Max. 10	—
Solid component [％]	19.0 to 21.0	Min. 95.0
Density at 20℃ [g/ml]	1.039 to 1.050	—
pH-Value at 25℃	4 to 6	4 to 7
Absorbance value (1%, 237nm)	Min. 400	Min. 400
Absorbance ratio (237nm / 222nm)	1.2 to 1.6	1.2 to 1.6

Areas of application:
PHMB is widely used in oil field chemicals, water treatment chemicals, daily chemicals, textile printing and dyeing, swimming pool disinfection, flower antiseptic treatment, animal husbandry, aquaculture, agriculture, pet antibacterial, soil improvement, environmental disinfection, disinfection products, etc.
In aquaculture, HPMB can rapidly inhibit Gram-negative bacteria, floating Vibrio, Vibrio parahaemolyticus, Vibrio algolyticus and other harmful bacteria in seawater, and has good preventive and therapeutic effects on various diseases caused by bacteria in South American white shrimp and other aquatic products.

Chemical Name:
Poly(iminoimidocarbonyliminoimidocarbonyliminohexamethylene),hydrochloride;
Poly(hexamethylenebiguanide) hydrochloride;
Poly(iminocarbonimidoyliminocarbonimidoylimino-1,6-hexanediyl), hydrochloride;
Poly(hexamethylene diguanide) hydrochloride；
Poly[imino(carbonimidoyl)imino(carbonimidoyl)iminohexane-1,6-diyl] hydrochloride (1:?);
Guanidine,N,N”’-1,6-hexanediylbis[N’-cyano-,polymer with 1,6-hexanediamine, hydrochloride;
N,N”’-1,6-Hexanediylbis(N’-cyanoguanidine),hexamethylenediamine polymer, hydrochloride;